Difference between Insane and Screw Loose

INSANE vs SCREW LOOSE: ADJECTIVE

Afflicted with or characteristic of mental derangement
Of, exhibiting, or afflicted with mental derangement. Not used in psychiatric diagnosis.
Characteristic of or associated with persons who are mentally deranged.
Intended for use by such persons.
Having been determined to be in a condition that meets the legal definition of insanity.
Immoderate; wild.
Very foolish; absurd.
Exhibiting unsoundness or disorder of mind; not sane; mad; deranged in mind; delirious; distracted. See insanity, 2.
Used by, or appropriated to, insane persons.
Causing insanity or madness.
Characterized by insanity or the utmost folly; chimerical; unpractical
Very foolish

Synonyms Crazed, lunatic, demented, maniacal.
Making insane; causing insanity.
Devoted to the use or care of the insane: as, an insane asylum.
Characteristic of a person mentally deranged; hence, wild; insensate; senseless.
Not sane; unsound or deranged in mind; crazy.

Nutty, Schizophrenic, Paranoid, Loony, Batty, Maniac, Psychotic, Unhinged, Deranged, Demented, Idiotic, Mad, Bonkers, Lunatic, Crazy

Nutty, Schizophrenic, Paranoid, Loony, Batty, Maniac, Psychotic, Unhinged, Deranged, Demented, Idiotic, Mad, Bonkers, Lunatic, Crazy

This whole situation is insane and quite frankly is making me insane.
This is one insane quest fit for one insane faction of isolated geniuses.
Even if not deemed legally insane, a serial killer is certainly morally and ethnically insane.
If you want to demonstrate that someone is insane, then they gotta fucking look insane.
He acts insane but tries to insist I am the one who is insane.
Do people living through insane times realize just how insane that time is?
Asa was insane; but Asa was insane because the deed itself was insane.
Finally, I went insane, and not the good kind of insane either.
The people are all insane, the other animals are all insane, the earth is insane, Nature itself is insane.
Insane stunting circuits, insane jumps, insane speeds: Trackmania Turbo has it all.

Hurley knew he had his own issues, but he was starting to worry that Rapp had a screw loose.
"I have a screw loose," he adds with a laugh.
Express Gambling Lady The Perfect Tenant Screw Loose Dil Ki Baazi Hand Gun Gall Force: Vol.
Benny thought the Mayor had a screw loose.
There is a screw loose somewhere, and the sooner that screw is tightened up the better.